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Clinical eligibility (diagnosis, medication history, tremor severity), technical eligibility (SDR ≥ 0.4), and the full same-day assessment pathway — for essential tremor and tremor-dominant Parkinson's disease at KIMS Neuroscience, Secunderabad, Hyderabad.
Not everyone with essential tremor or Parkinson's disease tremor is a candidate for MRgFUS. Eligibility is determined by a combination of clinical criteria (the diagnosis, severity, and medication history) and a technical criterion that is unique to focused ultrasound — the skull density ratio (SDR). Understanding both categories of eligibility helps patients know whether it is worth coming for an assessment, and what the assessment at KIMS will involve.
Same-day eligibility assessment — clinical review, skull CT for SDR calculation, and brain MRI in a single visit.
040-44885000Emergency line: 040-46324365The skull density ratio (SDR) is a measurement derived from a CT scan of the head that reflects how well ultrasound energy can pass through the individual patient's skull bone. An SDR of 1.0 represents a skull that transmits ultrasound perfectly; an SDR of 0.0 represents a skull that blocks ultrasound completely. Patients with an SDR of 0.4 or above are eligible for MRgFUS; those below 0.4 cannot be adequately treated because insufficient ultrasound energy reaches the brain target.
MRgFUS eligibility rests on four pillars — clinical eligibility, the SDR threshold, MRI compatibility, and procedure tolerance. Each is assessed in the same-day pathway at KIMS.
Essential tremor or tremor-dominant Parkinson's disease that has failed at least two appropriate medications (propranolol + primidone for ET; levodopa-carbidopa ± agonists for PD), with tremor severity that significantly impairs daily function on the TETRAS or MDS-UPDRS.
Calculated from a thin-slice CT — measures how well ultrasound can pass through the patient's specific skull bone. Approximately 20–30% of otherwise eligible patients have an SDR below 0.4 and cannot be treated by MRgFUS.
No non-MRI-compatible pacemaker, defibrillator, cochlear implant, or head/brain metal hardware. Hip replacements, spinal hardware, coronary stents, and most modern body implants are MRI-compatible and do not exclude the patient.
Able to lie flat in an MRI scanner for 1.5–2 hours · Able to give verbal feedback during the procedure · No severe claustrophobia unresponsive to anxiolytics · No active severe psychiatric illness · No significant coagulopathy.
MRgFUS is FDA-approved and clinically established at KIMS for two indications: (1) Essential tremor (ET) of the hand and arm: the most common movement disorder in adults over 60. The tremor occurs during action (reaching, holding a glass, writing) and is not present at rest. (2) Tremor-dominant Parkinson's disease: the resting tremor of Parkinson's disease in the dominant hand, where tremor is the most disabling feature. MRgFUS is not currently used for: tremor from multiple sclerosis · Cerebellar ataxia-related tremor · Drug-induced tremor · Dystonic tremor · Psychogenic tremor · Parkinson's disease where bradykinesia and rigidity are the primary complaints (DBS is more appropriate).
MRgFUS is not first-line treatment. The clinical criterion requires that the patient has: tried and failed at least two appropriate medications for their tremor type · For ET: propranolol (or atenolol if propranolol is not tolerated) AND primidone at adequate doses · For PD tremor: levodopa-carbidopa at adequate doses, with or without dopamine agonists · “Failed” means either the medication was not effective (inadequate tremor control) or the side effects were not tolerable at the doses needed for tremor control. Patients who have never tried medical treatment will be offered medication optimisation before MRgFUS is considered.
MRgFUS is appropriate when the tremor significantly impairs daily function. The KIMS assessment uses standardised tremor severity scales (the Essential Tremor Rating Assessment Scale, ETRAS, and the TETRAS — The Essential Tremor Rating Assessment Scale for ET; the MDS-UPDRS tremor subscale for PD) to document severity. Patients with mild tremor that does not significantly interfere with daily activities are typically counselled to continue with medication optimisation before proceeding to MRgFUS.
MRgFUS has no strict upper age limit. The oldest patients treated in clinical trials were in their 80s. General health requirements: the patient must be able to lie flat in an MRI scanner for 1.5–2 hours without significant discomfort (patients with severe musculoskeletal conditions may have difficulty) · Cognitive function must be sufficient to provide feedback during the procedure · No severe anxiety or claustrophobia that cannot be managed with anxiolytics · No significant coagulopathy (the frame pins penetrate the scalp; abnormal bleeding would be a problem).
Ultrasound waves interact with bone differently from soft tissue. When ultrasound travels through bone, it is partially reflected, partially scattered, and partially absorbed as heat within the bone itself. If the skull bone is very dense (thick compact bone with little porous structure), a large proportion of the ultrasound energy is absorbed and reflected by the bone rather than transmitted to the brain. This reduces the energy available at the target and causes the skull to heat up — which must be managed by simultaneous skull cooling. If the skull bone is excessively absorptive (SDR below 0.4), insufficient energy reaches the Vim thalamus to create an effective lesion, even at maximum power.
The SDR is calculated from a thin-slice CT scan of the head (1 mm slices). The CT measures the X-ray attenuation (density) of the skull bone at many points. The SDR formula compares the density of the inner and outer cortical bone layers (compact bone, high density) to the diploe (the spongy cancellous bone between them, low density). A skull with high SDR has thin, dense cortical layers and a thick, porous diploe — this structure transmits ultrasound well. A skull with low SDR has very thick, uniformly dense bone that absorbs rather than transmits ultrasound. The CT for SDR measurement is performed at KIMS as part of the eligibility assessment and the result is available the same day. The KIMS team calculates the SDR using the Insightec-validated algorithm.
Approximately 20–30% of patients who are clinically eligible for MRgFUS (correct diagnosis, failed medications, adequate tremor severity) have an SDR below 0.4 and cannot be treated. For these patients, the alternatives are: (1) RF thalamotomy (radiofrequency thalamotomy): the most direct surgical comparator to MRgFUS — it creates the same permanent Vim thalamic lesion, but through a burr hole and an inserted electrode rather than ultrasound, so skull density is irrelevant. (2) DBS (deep brain stimulation): there is no skull bone requirement for DBS; the electrodes are placed surgically and do not require ultrasound transmission. (3) Stereotactic radiosurgery (Gamma Knife thalamotomy): delivers radiation to the Vim target without skull bone transmission requirements, though with a latency of 4–12 months before the lesion is fully effective. The KIMS team discusses these alternatives with all patients who are found to be ineligible for MRgFUS due to SDR.
The table below summarises the exclusion criteria for MRgFUS at KIMS, the reason for exclusion, and the preferred alternative treatment pathway.
Exclusion Criterion
Reason
Alternative
Insufficient ultrasound transmission through skull
RF thalamotomy · DBS · Gamma Knife thalamotomy
MRI incompatible
Discuss with cardiologist — MRI-compatible devices sometimes eligible
MRI contraindication
DBS
MRI safety
Case-by-case evaluation
Cannot provide reliable intraoperative feedback
Stabilise psychiatric condition first
Cannot tolerate MRI scanner for 1.5–2 hours
DBS if tremor is severe
Procedure risk
Medically optimise and reassess
Frame pin site bleeding risk
Adjust anticoagulation (discuss with haematologist)
Cannot provide reliable feedback · DBS may be inappropriate too
Palliative management
MRgFUS is unilateral only
DBS (bilateral stimulation is standard for bilateral tremor)
No evidence base · Not approved
Disease-specific management
The full eligibility assessment proceeds in four sequential stages — completed in a single day with a same-day result and same-day consultation.
Detailed movement disorder history · Medication history review · TETRAS or UPDRS tremor scoring · Neurological examination · Functional assessment (observe writing, pouring water, Archimedes spiral drawing) · Cognitive screening · Psychiatric history · Cardiac and medical history review.
Low-dose thin-slice (1 mm) CT of the head without contrast: assesses the skull density ratio and bone suitability for ultrasound transmission. Takes 5–10 minutes. Results available within 1–2 hours using the Insightec algorithm. This is the most important eligibility test because it determines whether MRgFUS is technically feasible for that patient, so it is performed before the MRI.
3 Tesla MRI of the brain: confirms the target anatomy, identifies the thalamic target for planning, and checks for contraindications and structural abnormalities (tumour, haemorrhage, significant small vessel disease) that might affect safety or outcome. Can be performed at KIMS on the same day as the assessment if not recently available.
The KIMS MRgFUS team reviews all assessment data (clinical, CT/SDR, MRI) and provides a same-day eligibility decision and consultation. If eligible: procedure scheduling, pre-procedure instructions, and consent discussion. If not eligible due to SDR: discussion of alternatives (RF thalamotomy, DBS, Gamma Knife thalamotomy). If not eligible due to clinical criteria: medication optimisation plan or watchful waiting recommendation.
MRgFUS eligibility at KIMS is decided in a single day on the basis of clinical and technical criteria. The following points summarise the most clinically significant facts every patient and referring physician should know.
MRgFUS is FDA-approved and offered at KIMS for essential tremor and tremor-dominant Parkinson's disease — not for MS, cerebellar ataxia, dystonic, drug-induced, or psychogenic tremor
Failed medical treatment is a prerequisite — propranolol + primidone for ET; levodopa-carbidopa ± agonists for PD tremor — at adequate doses, with documented inefficacy or intolerable side effects
Skull Density Ratio (SDR) is calculated from a thin-slice 1 mm CT using the Insightec-validated algorithm — KIMS provides same-day results
Approximately 20–30% of otherwise eligible patients have an SDR below 0.4 and are not technically treatable by MRgFUS — RF thalamotomy, DBS, and Gamma Knife thalamotomy are the alternatives at KIMS
There is no upper age limit — published series include patients in their late 70s and 80s with tremor reduction equivalent to younger patients
MRgFUS is unilateral only — bilateral thalamotomy significantly increases the risk of permanent dysarthria and swallowing problems
Hip replacements, spinal hardware, and coronary stents are MRI-compatible and not exclusions — only head/brain metal implants and older pacemakers are MRI contraindications
The full KIMS eligibility assessment (clinical review + skull CT/SDR + 3T MRI) is completed in a single day with a same-day result
| Fact | Details |
|---|---|
| Clinical eligibility | Diagnosis: ET or tremor-dominant PD · Failed ≥ 2 appropriate medications at adequate doses · Significant functional disability from tremor · TETRAS/MDS-UPDRS documented |
| Technical eligibility — SDR | Skull Density Ratio ≥ 0.4 on thin-slice CT · 20–30% of otherwise eligible patients excluded here · SDR cannot be changed · Same-day CT + SDR calculation at KIMS |
| MRI compatibility | No non-MRI-compatible pacemaker, defibrillator, cochlear implant, or head/brain metal · Hip replacements, spinal hardware, coronary stents generally compatible · Confirmed from device model numbers |
| Procedure tolerance | Able to lie flat 1.5–2 hours · Verbal feedback during procedure · No severe unresponsive claustrophobia · No significant coagulopathy · No strict upper age limit (oldest trial patients in their 80s) |
| Conditions NOT treatable | MS tremor · Cerebellar ataxia-related tremor · Drug-induced tremor · Dystonic tremor · Psychogenic tremor · PD where bradykinesia and rigidity dominate |
| Same-day eligibility assessment | 1 visit: 60–90 min clinical consultation + CT (SDR) + 3T MRI + same-day eligibility decision + consent · Combined 2-day visit with treatment for out-of-Hyderabad patients |
| Contact | 040-44885000 · neuroscience@kimshospitals.com · No referral required · Eligibility can be pre-screened by phone/email before the visit |
Explore related MRgFUS, DBS, and Gamma Knife pages at KIMS Neuroscience:
Find Out in a Single Day Whether MRgFUS is the Right Treatment for Your Tremor — at KIMS Hyderabad.
Find out in a single day whether MRgFUS is the right treatment for your tremor. The KIMS MRgFUS eligibility assessment — including clinical review, skull CT for SDR calculation, and brain MRI — is completed in one visit with a same-day result. Call 040-44885000.
International enquiries: info@kimsneurosciences.com